Safety and Efficacy of High Dose AAV9 Encoding SERCA2a Delivered by Molecular Cardiac Surgery with Recirculating Delivery (MCARD) in Ovine Ischemic Cardiomyopathy

OBJECTIVE: Therapeutic safety and efficacy are the basic prerequisites for clinical gene therapy. Herein we investigate the effect of high dose MCARD-mediated AAV9/SERCA2a gene delivery on clinical parameters, oxidative stress, humoral and cellular immune response, and cardiac remodeling. METHODS: I...

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Autors principals: Katz, Michael G., Fargnoli, Anthony S., Williams, Richard D., Steuerwald, Nury M., Isidro, Alice, Ivanina, Anna V., Sokolova, Inna M., Bridges, Charles R.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170593/
https://ncbi.nlm.nih.gov/pubmed/25037619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2014.05.070
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