GATA-3 dose-dependent checkpoints in early T cell commitment()

GATA-3 expression is crucial for T cell development and peaks during commitment to the T-cell lineage, midway through the CD4(−)CD8(−) (DN) 1-3 stages. We used RNA interference and conditional deletion to reduce GATA-3 protein acutely at specific points during T-cell differentiation in vitro. Even m...

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Autores principales: Scripture-Adams, Deirdre D., Damle, Sagar S., Li, Long, Elihu, Koorosh J., Qin, Shuyang, Arias, Alexandra M., Butler, Robert R., Champhekar, Ameya, Zhang, Jingli A., Rothenberg, Ellen V.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170028/
https://ncbi.nlm.nih.gov/pubmed/25172496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301663
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