Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling

The immune-regulatory cytokine IL-10 plays a central role during innate and adaptive immune responses. IL-10 is elevated in the serum and tissues of patients with systemic lupus erythematosus (SLE), an autoimmune disorder characterized by autoantibody production, immune-complex formation, and altere...

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Detalhes bibliográficos
Main Authors: Hedrich, Christian M., Rauen, Thomas, Apostolidis, Sokratis A., Grammatikos, Alexandros P., Rodriguez Rodriguez, Noe, Ioannidis, Christina, Kyttaris, Vasileios C., Crispin, Jose C., Tsokos, George C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169908/
https://ncbi.nlm.nih.gov/pubmed/25187566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408023111
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