Protein Phosphatase 2A Enables Expression of Interleukin 17 (IL-17) through Chromatin Remodeling

Protein phosphatase 2A (PP2A) is a heterotrimeric serine/threonine phosphatase involved in essential cellular functions. T cells from patients with systemic lupus erythematosus (SLE) express high levels of the catalytic subunit of PP2A (PP2Ac). A mouse overexpressing PP2Ac in T cells develops glomer...

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Hauptverfasser: Apostolidis, Sokratis A., Rauen, Thomas, Hedrich, Christian M., Tsokos, George C., Crispín, José C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772223/
https://ncbi.nlm.nih.gov/pubmed/23918926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.483743
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