The Strong In Vivo Anti-Tumor Effect of the UIC2 Monoclonal Antibody Is the Combined Result of Pgp Inhibition and Antibody Dependent Cell-Mediated Cytotoxicity

P-glycoprotein (Pgp) extrudes a large variety of chemotherapeutic drugs from the cells, causing multidrug resistance (MDR). The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10–40% of cell surface...

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Auteurs principaux: Szalóki, Gábor, Krasznai, Zoárd T., Tóth, Ágnes, Vízkeleti, Laura, Szöllősi, Attila G., Trencsényi, György, Lajtos, Imre, Juhász, István, Krasznai, Zoltán, Márián, Teréz, Balázs, Margit, Szabó, Gábor, Goda, Katalin
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169599/
https://ncbi.nlm.nih.gov/pubmed/25238617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107875
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