The Strong In Vivo Anti-Tumor Effect of the UIC2 Monoclonal Antibody Is the Combined Result of Pgp Inhibition and Antibody Dependent Cell-Mediated Cytotoxicity

P-glycoprotein (Pgp) extrudes a large variety of chemotherapeutic drugs from the cells, causing multidrug resistance (MDR). The UIC2 monoclonal antibody recognizes human Pgp and inhibits its drug transport activity. However, this inhibition is partial, since UIC2 binds only to 10–40% of cell surface...

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Main Authors: Szalóki, Gábor, Krasznai, Zoárd T., Tóth, Ágnes, Vízkeleti, Laura, Szöllősi, Attila G., Trencsényi, György, Lajtos, Imre, Juhász, István, Krasznai, Zoltán, Márián, Teréz, Balázs, Margit, Szabó, Gábor, Goda, Katalin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169599/
https://ncbi.nlm.nih.gov/pubmed/25238617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107875
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