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Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA
By using a microscopic approach, field inversion single-cell gel electrophoresis, we show that preformed single-strand discontinuities are present in the chromatin of resting and proliferating mammalian and yeast cells. These single-strand breaks are primarily nicks positioned at ≈50-kbp intervals t...
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| Главные авторы: | , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1986596/ https://ncbi.nlm.nih.gov/pubmed/17848525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702269104 |
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