Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA

By using a microscopic approach, field inversion single-cell gel electrophoresis, we show that preformed single-strand discontinuities are present in the chromatin of resting and proliferating mammalian and yeast cells. These single-strand breaks are primarily nicks positioned at ≈50-kbp intervals t...

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Detalhes bibliográficos
Main Authors: Székvölgyi, Lóránt, Rákosy, Zsuzsa, Bálint, Bálint L., Kókai, Endre, Imre, László, Vereb, György, Bacsó, Zsolt, Goda, Katalin, Varga, Sándor, Balázs, Margit, Dombrádi, Viktor, Nagy, László, Szabó, Gábor
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986596/
https://ncbi.nlm.nih.gov/pubmed/17848525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702269104
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