tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

Nonessential tRNA modifications by methyltransferases are evolutionarily conserved and have been reported to stabilize mature tRNA molecules and prevent rapid tRNA decay (RTD). The tRNA modifying enzymes, NSUN2 and METTL1, are mammalian orthologs of yeast Trm4 and Trm8, which are required for protec...

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Bibliografiske detaljer
Main Authors: Okamoto, Mayumi, Fujiwara, Mamoru, Hori, Masato, Okada, Kaoru, Yazama, Futoshi, Konishi, Hiroaki, Xiao, Yegui, Qi, Guangying, Shimamoto, Fumio, Ota, Takahide, Temme, Achim, Tatsuka, Masaaki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169382/
https://ncbi.nlm.nih.gov/pubmed/25233213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004639
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