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Total Synthesis of Δ(12)-Prostaglandin J(3), a Highly Potent and Selective Antileukemic Agent
A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ(12)-prostaglandin J(3) (Δ(12)-PGJ(3)) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively from readily available starting materials and coupled through an aldo...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169176/ https://ncbi.nlm.nih.gov/pubmed/25098181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201404917 |
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