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15-Deoxy-Δ(12,14)-prostaglandin J(2) inhibits HIV-1 transactivating protein, Tat, through covalent modification
Controlling the HIV/AIDS epidemic remains a major challenge, with approximately 5 million new HIV infections annually. Cyclopentenone prostaglandins (CyPG), such as 15-deoxy-Δ(12,14)-PGJ(2) (15d-PGJ(2)), are arachidonic acid-derived endogenous electrophiles that possess anti-HIV activity by an unkno...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Federation of American Societies for Experimental Biology
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2717765/ https://ncbi.nlm.nih.gov/pubmed/19299483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-124982 |
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