15-Deoxy-Δ(12,14)-prostaglandin J(2) inhibits HIV-1 transactivating protein, Tat, through covalent modification

Controlling the HIV/AIDS epidemic remains a major challenge, with approximately 5 million new HIV infections annually. Cyclopentenone prostaglandins (CyPG), such as 15-deoxy-Δ(12,14)-PGJ(2) (15d-PGJ(2)), are arachidonic acid-derived endogenous electrophiles that possess anti-HIV activity by an unkno...

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Detalhes bibliográficos
Main Authors: Kalantari, Parisa, Narayan, Vivek, Henderson, Andrew J., Prabhu, K. Sandeep
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717765/
https://ncbi.nlm.nih.gov/pubmed/19299483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-124982
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