Total Synthesis of Δ(12)-Prostaglandin J(3), a Highly Potent and Selective Antileukemic Agent

A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ(12)-prostaglandin J(3) (Δ(12)-PGJ(3)) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively from readily available starting materials and coupled through an aldo...

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Detalhes bibliográficos
Main Authors: Nicolaou, K. C., Heretsch, Philipp, ElMarrouni, Abdelatif, Hale, Christopher R. H., Pulukuri, Kiran K., Kudva, Avinash K., Narayan, Vivek, Sandeep Prabhu, K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169176/
https://ncbi.nlm.nih.gov/pubmed/25098181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201404917
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