(124)I-Labeled Engineered Anti-CEA Minibodies and Diabodies Allow High-Contrast, Antigen-Specific Small-Animal PET Imaging of Xenografts in Athymic Mice

Prolonged clearance kinetics have hampered the development of intact antibodies as imaging agents, despite their ability to effectively deliver radionuclides to tumor targets in vivo. Genetically engineered antibody fragments display rapid, high-level tumor uptake coupled with rapid clearance from t...

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Main Authors: Sundaresan, Gobalakrishnan, Yazaki, Paul J., Shively, John E., Finn, Ronald D., Larson, Steven M., Raubitschek, Andrew A., Williams, Lawrence E., Chatziioannou, Arion F., Gambhir, Sanjiv S., Wu, Anna M.
Formato: Artigo
Idioma:Inglês
Publicado: 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167879/
https://ncbi.nlm.nih.gov/pubmed/14660722
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