Tailoring the Pharmacokinetics and Positron Emission Tomography Imaging Properties of Anti–Carcinoembryonic Antigen Single-Chain Fv-Fc Antibody Fragments

Antibody fragments are recognized as promising vehicles for delivery of imaging and therapeutic agents to tumor sites in vivo. The serum persistence of IgG1 and fragments with intact Fc region is controlled by the protective neonatal Fc receptor (FcRn) receptor. To modulate the half-life of engineer...

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Main Authors: Kenanova, Vania, Olafsen, Tove, Crow, Desiree M., Sundaresan, Gobalakrishnan, Subbarayan, Murugesan, Carter, Nora H., Ikle, David N., Yazaki, Paul J., Chatziioannou, Arion F., Gambhir, Sanjiv S., Williams, Lawrence E., Shively, John E., Colcher, David, Raubitschek, Andrew A., Wu, Anna M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154799/
https://ncbi.nlm.nih.gov/pubmed/15695407
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