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Optimizing Radiolabeled Engineered Anti-p185(HER2) Antibody Fragments for In vivo Imaging

We have recently described the in vivo properties of an iodinated anti-p185(HER2) engineered antibody fragment [minibody (scFv-C(H)3)(2); 80 kDa], made from the internalizing 10H8 monoclonal antibody. Although the 10H8 minibody showed excellent binding to the target in vitro, only modest tumor uptak...

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Main Authors:	Olafsen, Tove, Kenanova, Vania E., Sundaresan, Gobalakrishnan, Anderson, Anne-Line, Crow, Desiree, Yazaki, Paul J., Li, Lin, Press, Michael F., Gambhir, Sanjiv S., Williams, Lawrence E., Wong, Jeffrey Y.C., Raubitschek, Andrew A., Shively, John E., Wu, Anna M.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2005
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4161125/ https://ncbi.nlm.nih.gov/pubmed/15994969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-04-4472
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

Optimizing Radiolabeled Engineered Anti-p185(HER2) Antibody Fragments for In vivo Imaging

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