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Optimizing Radiolabeled Engineered Anti-p185(HER2) Antibody Fragments for In vivo Imaging
We have recently described the in vivo properties of an iodinated anti-p185(HER2) engineered antibody fragment [minibody (scFv-C(H)3)(2); 80 kDa], made from the internalizing 10H8 monoclonal antibody. Although the 10H8 minibody showed excellent binding to the target in vitro, only modest tumor uptak...
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Main Authors: | , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2005
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4161125/ https://ncbi.nlm.nih.gov/pubmed/15994969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-04-4472 |
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