Optimizing Radiolabeled Engineered Anti-p185(HER2) Antibody Fragments for In vivo Imaging

We have recently described the in vivo properties of an iodinated anti-p185(HER2) engineered antibody fragment [minibody (scFv-C(H)3)(2); 80 kDa], made from the internalizing 10H8 monoclonal antibody. Although the 10H8 minibody showed excellent binding to the target in vitro, only modest tumor uptak...

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Main Authors: Olafsen, Tove, Kenanova, Vania E., Sundaresan, Gobalakrishnan, Anderson, Anne-Line, Crow, Desiree, Yazaki, Paul J., Li, Lin, Press, Michael F., Gambhir, Sanjiv S., Williams, Lawrence E., Wong, Jeffrey Y.C., Raubitschek, Andrew A., Shively, John E., Wu, Anna M.
Format: Artigo
Jezik:Inglês
Izdano: 2005
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161125/
https://ncbi.nlm.nih.gov/pubmed/15994969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-04-4472
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