The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF

Following mutations in BRAF and NRAS, the RAC1 c.85C>T single nucleotide variant (SNV) encoding P29S amino acid change represents the next most frequently observed protein-coding hotspot mutation in melanoma. However, the biological and clinical significance of the RAC1 P29S somatic mutation in a...

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Main Authors: Watson, Ian R., Li, Liren, Cabeceiras, Peter K., Mahdavi, Mozhdeh, Gutschner, Tony, Genovese, Giannicola, Wang, Guocan, Fang, Zhuangna, Tepper, James M., Stemke-Hale, Katherine, Tsai, Kenneth Y., Davies, Michael A., Mills, Gordon B., Chin, Lynda
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167745/
https://ncbi.nlm.nih.gov/pubmed/25056119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1232-T
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