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RAC1(P29S) is a spontaneously activating cancer-associated GTPase

RAC1 is a small, Ras-related GTPase that was recently reported to harbor a recurrent UV-induced signature mutation in melanoma, resulting in substitution of P29 to serine (RAC1(P29S)), ranking this the third most frequently occurring gain-of-function mutation in melanoma. Although the Ras family GTP...

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Detalhes bibliográficos
Principais autores: Davis, Matthew J., Ha, Byung Hak, Holman, Edna C., Halaban, Ruth, Schlessinger, Joseph, Boggon, Titus J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549122/
https://ncbi.nlm.nih.gov/pubmed/23284172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220895110
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