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5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties

A series of novel 5-((1-aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones (3a–z) have been evaluated for in vitro cytotoxicity against a panel of 60 human tumor cell lines. Compound 3k exhibited the most potent growth inhibition against melanoma MDA-MB-435 cells (GI(50)=850...

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Main Authors: Penthala, Narsimha Reddy, Ponugoti, Purushothama Rao, Kasam, Vinod, Crooks, Peter A.
格式: Artigo
語言:Inglês
出版: 2012
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167626/
https://ncbi.nlm.nih.gov/pubmed/23339966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.12.053
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