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Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines

Based on previous SAR studies on N-benzylindole and barbituric acid hybrid molecules, we have synthesized a series of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs (3a–i) and evaluated them for their in vitro growth inhibition and cy...

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Bibliografiske detaljer
Main Authors: Madadi, Nikhil Reddy, Penthala, Narsimha Reddy, Janganati, Venumadhav, Crooks, Peter A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954641/
https://ncbi.nlm.nih.gov/pubmed/24361000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.12.013
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