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Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines

The synthesis of several novel substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones structurally related to aplysinopsin have been carried out under microwave irradiation and conventional heating methods. The analogs 3a, 3b, 3d–3g, and 3k and 3l were evaluated...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Penthala, Narsimha Reddy, Yerramreddy, Thirupathi Reddy, Crooks, Peter A
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414060/
https://ncbi.nlm.nih.gov/pubmed/20006496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.11.083
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