Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection

The need for γ-retroviral (gRV) vectors with a self-inactivating (SIN) design for clinical application has prompted a shift in methodology of vector manufacturing from the traditional use of stable producer lines to transient transfection-based techniques. Herein, we set out to define and optimize a...

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Detalhes bibliográficos
Main Authors: van der Loo, JCM, Swaney, WP, Grassman, E, Terwilliger, A, Higashimoto, T, Schambach, A, Baum, C, Thrasher, AJ, Williams, DA, Nordling, DL, Reeves, L, Malik, P
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167414/
https://ncbi.nlm.nih.gov/pubmed/21753795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.102
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