Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

BACKGROUND: Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution. RESULTS: We perform whole exome sequencing on four clear cell renal cell carcinomas removed from both kidneys of a patient with a ge...

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Detalhes bibliográficos
Main Authors: Fisher, Rosalie, Horswell, Stuart, Rowan, Andrew, Salm, Maximilian P, de Bruin, Elza C, Gulati, Sakshi, McGranahan, Nicholas, Stares, Mark, Gerlinger, Marco, Varela, Ignacio, Crockford, Andrew, Favero, Francesco, Quidville, Virginie, André, Fabrice, Navas, Carolina, Grönroos, Eva, Nicol, David, Hazell, Steve, Hrouda, David, O’Brien, Tim, Matthews, Nik, Phillimore, Ben, Begum, Sharmin, Rabinowitz, Adam, Biggs, Jennifer, Bates, Paul A, McDonald, Neil Q, Stamp, Gordon, Spencer-Dene, Bradley, Hsieh, James J, Xu, Jianing, Pickering, Lisa, Gore, Martin, Larkin, James, Swanton, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166471/
https://ncbi.nlm.nih.gov/pubmed/25159823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0433-z
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