Adeno-Associated Virus Type 2 VP2 Capsid Protein Is Nonessential and Can Tolerate Large Peptide Insertions at Its N Terminus

Direct insertion of amino acid sequences into the adeno-associated virus type 2 (AAV) capsid open reading frame (cap ORF) is one strategy currently being developed for retargeting this prototypical gene therapy vector. While this approach has successfully resulted in the formation of AAV particles t...

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Detalhes bibliográficos
Main Authors: Warrington, Kenneth H., Gorbatyuk, Oleg S., Harrison, Jeffrey K., Opie, Shaun R., Zolotukhin, Sergei, Muzyczka, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC416546/
https://ncbi.nlm.nih.gov/pubmed/15163751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.12.6595-6609.2004
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