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Emerging Insights into the Mechanistic Link between α-Synuclein and Glucocerebrosidase in Parkinson's Disease

Mutations in the GBA1 gene, encoding the enzyme glucocerebrosidase, cause the lysosomal storage disorder, Gaucher disease (GD), and are associated with the development of Parkinson's disease (PD) and other Lewy body disorders. Interestingly, GBA1 variants are the most common genetic risk factor...

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Main Authors: McGlinchey, Ryan P., Lee, Jennifer C.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164968/
https://ncbi.nlm.nih.gov/pubmed/24256245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20130158
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