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Immunoglobulin Heavy Chain Variable Region and Major Histocompatibility Region Genes Are Linked to Induced Graves' Disease in Females From Two Very Large Families of Recombinant Inbred Mice

Graves' hyperthyroidism is caused by antibodies to the TSH receptor (TSHR) that mimic thyroid stimulation by TSH. Stimulating TSHR antibodies and hyperthyroidism can be induced by immunizing mice with adenovirus expressing the human TSHR A-subunit. Prior analysis of induced Graves' disease...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: McLachlan, Sandra M., Aliesky, Holly, Banuelos, Bianca, Magana, Jessica, Williams, Robert W., Rapoport, Basil
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Endocrine Society 2014
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164918/
https://ncbi.nlm.nih.gov/pubmed/25051451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1388
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