Immunoglobulin Heavy Chain Variable Region and Major Histocompatibility Region Genes Are Linked to Induced Graves' Disease in Females From Two Very Large Families of Recombinant Inbred Mice

Graves' hyperthyroidism is caused by antibodies to the TSH receptor (TSHR) that mimic thyroid stimulation by TSH. Stimulating TSHR antibodies and hyperthyroidism can be induced by immunizing mice with adenovirus expressing the human TSHR A-subunit. Prior analysis of induced Graves' disease...

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Hlavní autoři: McLachlan, Sandra M., Aliesky, Holly, Banuelos, Bianca, Magana, Jessica, Williams, Robert W., Rapoport, Basil
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2014
Témata:
Thyroid-TRH-TSH
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164918/
https://ncbi.nlm.nih.gov/pubmed/25051451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1388
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