BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

Apoptosis is a highly regulated form of cell death that controls normal homeostasis as well as the anti-tumor activity of many chemotherapeutic agents. Commitment to death via the mitochondrial apoptotic pathway requires activation of the mitochondrial pore-forming proteins BAK or BAX. Activation ca...

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Hauptverfasser: Sarosiek, Kristopher A., Chi, Xiaoke, Bachman, John A., Sims, Joshua J., Montero, Joan, Patel, Luv, Flanagan, Annabelle, Andrews, David W., Sorger, Peter, Letai, Anthony
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164233/
https://ncbi.nlm.nih.gov/pubmed/24074954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.08.048
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