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The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production

Flaviviruses are emerging human pathogens and worldwide health threats. During infection, a pathogenic, subgenomic flaviviral RNAs (sfRNAs) are produced by resisting degradation by the 5’→3’ host cell exonuclease Xrn1 through an unknown RNA structure-based mechanism. Here, we present the crystal str...

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Autori principali: Chapman, Erich G., Costantino, David A., Rabe, Jennifer L., Moon, Stephanie L., Wilusz, Jeffrey, Nix, Jay C., Kieft, Jeffrey S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163914/
https://ncbi.nlm.nih.gov/pubmed/24744377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1250897
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