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RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA
Dengue virus is a growing global health threat. Dengue and other flaviviruses commandeer the host cell’s RNA degradation machinery to generate the small flaviviral RNA (sfRNA), a noncoding RNA that induces cytopathicity and pathogenesis. Host cell exonuclease Xrn1 likely loads on the 5′ end of viral...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3968743/ https://ncbi.nlm.nih.gov/pubmed/24692447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01892 |
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