Nutlin-3 downregulates p53 phosphorylation on serine(392) and induces apoptosis in hepatocellular carcinoma cells

Drug-resistance and imbalance of apoptotic regulation limit chemotherapy clinical application for the human hepatocellular carcinoma (HCC) treatment. The reactivation of p53 is an attractive therapeutic strategy in cancer with disrupted-p53 function. Nutlin-3, a MDM2 antagonist, has antitumor activi...

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Библиографические подробности
Главные авторы: Shi, Xinli, Liu, Jingli, Ren, Laifeng, Mao, Nan, Tan, Fang, Ding, Nana, Yang, Jing, Li, Mingyuan
Формат: Artigo
Язык:Inglês
Опубликовано: Korean Society for Biochemistry and Molecular Biology 2014
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163890/
https://ncbi.nlm.nih.gov/pubmed/24286312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2014.47.4.146
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