MicroRNA Dysregulation in Liver and Pancreas of CMP-Neu5Ac Hydroxylase Null Mice Disrupts Insulin/PI3K-AKT Signaling

CMP-Neu5Ac hydroxylase (Cmah)-null mice fed with a high-fat diet develop fasting hyperglycemia, glucose intolerance, and pancreatic β-cell dysfunction and ultimately develop characteristics of type 2 diabetes. The precise metabolic role of the Cmah gene remains poorly understood. This study was desi...

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Hlavní autoři: Kwon, Deug-Nam, Chang, Byung-Soo, Kim, Jin-Hoi
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163447/
https://ncbi.nlm.nih.gov/pubmed/25243123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/236385
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