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N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH)

The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group addition catalyzed by CMP-Neu5Ac hydroxylase enzyme...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Perota, Andrea, Galli, Cesare
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803385/
https://ncbi.nlm.nih.gov/pubmed/31681287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02396
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