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Pancreatic β-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency
Type 2 diabetes is highly prevalent in human populations, particularly in obese individuals, and is characterized by progressive pancreatic β-cell dysfunction and insulin resistance. Most mammals, including Old World primates, express two major kinds of sialic acids, N-acetylneuraminic acid (Neu5Ac)...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Federation of American Societies for Experimental Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101031/ https://ncbi.nlm.nih.gov/pubmed/21350118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-175281 |
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