Pancreatic β-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency

Type 2 diabetes is highly prevalent in human populations, particularly in obese individuals, and is characterized by progressive pancreatic β-cell dysfunction and insulin resistance. Most mammals, including Old World primates, express two major kinds of sialic acids, N-acetylneuraminic acid (Neu5Ac)...

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Bibliographic Details
Main Authors: Kavaler, Sarah, Morinaga, Hidetaka, Jih, Alice, Fan, WuQiang, Hedlund, Maria, Varki, Ajit, Kim, Jane J.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2011
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101031/
https://ncbi.nlm.nih.gov/pubmed/21350118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-175281
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