ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling

OBJECTIVE: Aldehyde dehydrogenase (ALDH) expressing cells have been characterized as possessing stem cell-like properties. We evaluated ALDH+ ovarian cancer stem cell-like properties and their role in platinum resistance. METHODS: Isogenic ovarian cancer cell lines for platinum sensitivity (A2780) a...

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Hlavní autoři: Meng, Erhong, Mitra, Aparna, Tripathi, Kaushlendra, Finan, Michael A., Scalici, Jennifer, McClellan, Steve, da Silva, Luciana Madeira, Reed, Eddie, Shevde, Lalita A., Palle, Komaraiah, Rocconi, Rodney P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162571/
https://ncbi.nlm.nih.gov/pubmed/25216266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107142
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