Effect of siRNA with an Asymmetric RNA/dTdT Overhang on RNA Interference Activity

Small interfering RNAs (siRNAs) guide RNA-induced silencing complexes (RISC) to target mRNAs for sequence-specific silencing. A fundamental aspect of this highly coordinated process is a guide strand–specific loading of the siRNA duplex into the RISC for the accurate target recognition, which is cur...

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Hlavní autoři: Park, June Hyun, Hong, Sun Woo, Yun, Soyeong, Lee, Dong-ki, Shin, Chanseok
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2014
Témata:
Brief Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162433/
https://ncbi.nlm.nih.gov/pubmed/25211666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2014.0494
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