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MMP-2 Regulates Erk1/2 Phosphorylation and Aortic Dilatation in Marfan Syndrome
RATIONALE: Aneurysm and dissection of the ascending thoracic aorta are the main cardiovascular complication of Marfan Syndrome (MFS) resulting in premature death. Studies using mouse models of MFS have shown that activation of transforming growth factor (TGF)-β and the concomitant up-regulation of m...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4162309/ https://ncbi.nlm.nih.gov/pubmed/22550139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.268268 |
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