Premature aortic smooth muscle cell differentiation contributes to matrix dysregulation in Marfan Syndrome

Thoracic aortic aneurysm and dissection are life-threatening complications of Marfan syndrome (MFS). Studies of human and mouse aortic samples from late stage MFS demonstrate increased TGF-β activation/signaling and diffuse matrix changes. However, the role of the aortic smooth muscle cell (SMC) phe...

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Vydáno v:PLoS One
Hlavní autoři: Dale, Matthew, Fitzgerald, Matthew P., Liu, Zhibo, Meisinger, Trevor, Karpisek, Andrew, Purcell, Laura N., Carson, Jeffrey S., Harding, Paul, Lang, Haili, Koutakis, Panagiotis, Batra, Rishi, Mietus, Constance J., Casale, George, Pipinos, Iraklis, Baxter, B. Timothy, Xiong, Wanfen
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645122/
https://ncbi.nlm.nih.gov/pubmed/29040313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186603
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