Protein Kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity

Bones' strength is achieved and maintained through adaptation to load bearing. The role of the protein kinase PKCα in this process has not been previously reported. However, we observed a phenotype in the long bones of Prkca(−/−) female but not male mice, in which bone tissue progressively inva...

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Main Authors: Galea, Gabriel L., Meakin, Lee B., Williams, Christopher M., Hulin-Curtis, Sarah L., Lanyon, Lance E., Poole, Alastair W., Price, Joanna S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162157/
https://ncbi.nlm.nih.gov/pubmed/25070889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.580365
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