SPONTANEOUS TRANSMEMBRANE HELIX INSERTION THERMODYNAMICALLY MIMICS TRANSLOCON-GUIDED INSERTION

The favorable transfer free energy for a transmembrane (TM) α-helix between the aqueous phase and lipid bilayer underlies the stability of membrane proteins. However, the connection between the energetics and process of membrane protein assembly by the Sec61/SecY translocon complex in vivo is not cl...

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Bibliographic Details
Main Authors: Ulmschneider, Martin B., Ulmschneider, Jakob P., Schiller, Nina, Wallace, B. A., von Heijne, Gunnar, White, Stephen H.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161982/
https://ncbi.nlm.nih.gov/pubmed/25204588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5863
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