Plasmodium falciparum Infection Induces Expression of a Mosquito Salivary Protein (Agaphelin) That Targets Neutrophil Function and Inhibits Thrombosis without Impairing Hemostasis

BACKGROUND: Invasion of mosquito salivary glands (SGs) by Plasmodium falciparum sporozoites is an essential step in the malaria life cycle. How infection modulates gene expression, and affects hematophagy remains unclear. PRINCIPAL FINDINGS: Using Affimetrix chip microarray, we found that at least 4...

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Hauptverfasser: Waisberg, Michael, Molina-Cruz, Alvaro, Mizurini, Daniella M., Gera, Nidhi, Sousa, Beatriz C., Ma, Dongying, Leal, Ana C., Gomes, Tainá, Kotsyfakis, Michalis, Ribeiro, José M. C., Lukszo, Jan, Reiter, Karine, Porcella, Stephen F., Oliveira, Carlo J., Monteiro, Robson Q., Barillas-Mury, Carolina, Pierce, Susan K., Francischetti, Ivo M. B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161438/
https://ncbi.nlm.nih.gov/pubmed/25211214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004338
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