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Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation

Recently it was shown that the hematophagous salivary gland protein agaphelin exhibits multiple antithrombotic effects without promoting the risk of bleeding. Agaphelin inhibits neutrophil elastase and thereby reduces cathepsin G-induced platelet aggregation. However, it is still unclear, whether ph...

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Bibliografiska uppgifter
I publikationen:Brain Behav Immun
Huvudupphovsmän: Leinweber, Jonas, Mizurini, Daniella M., Francischetti, Ivo M.B., Fleischer, Michael, Hermann, Dirk M., Kleinschnitz, Christoph, Langhauser, Friederike
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979502/
https://ncbi.nlm.nih.gov/pubmed/33401017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2020.12.027
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