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A Highly Efficient Catalyst for Oxime Ligation and Hydrazone-Oxime Exchange Suitable for Bioconjugation

Imine-based reactions are useful for a wide range of bioconjugation applications. Although aniline is known to catalyze the oxime ligation reaction under physiological conditions, it suffers from slow reaction kinetics, specifically when a ketone is being used or when hydrazone-oxime exchange is per...

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Main Authors: Rashidian, Mohammad, Mahmoodi, Mohammad M., Shah, Rachit, Dozier, Jonathan K., Wagner, Carston R., Distefano, Mark D.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161282/
https://ncbi.nlm.nih.gov/pubmed/23425124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc3004167
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