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Evidence that the Fosfomycin-producing Epoxidase, HppE, is a Non-heme-iron Peroxidase()
The iron-dependent epoxidase, HppE, converts (S)-2-hydroxypropyl-1-phosphonate (S-HPP) to the antibiotic, fosfomycin [(1R, 2S)-epoxypropylphosphonate], in an unusual 1,3-dehydrogenation of a secondary alcohol to an epoxide. HppE has been classified as an oxidase, with proposed mechanisms differing p...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160821/ https://ncbi.nlm.nih.gov/pubmed/24114783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1240373 |
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