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Evidence that the Fosfomycin-producing Epoxidase, HppE, is a Non-heme-iron Peroxidase()

The iron-dependent epoxidase, HppE, converts (S)-2-hydroxypropyl-1-phosphonate (S-HPP) to the antibiotic, fosfomycin [(1R, 2S)-epoxypropylphosphonate], in an unusual 1,3-dehydrogenation of a secondary alcohol to an epoxide. HppE has been classified as an oxidase, with proposed mechanisms differing p...

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Bibliografiske detaljer
Main Authors: Wang, Chen, Chang, Wei-chen, Guo, Yisong, Huang, Hui, Peck, Spencer C., Pandelia, Maria E., Lin, Geng-min, Liu, Hung-wen, Krebs, Carsten, Bollinger, J. Martin
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160821/
https://ncbi.nlm.nih.gov/pubmed/24114783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1240373
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