Mechanistic Consequences of Chiral Radical Clock Probes: Analysis of the Mononuclear Non-Heme Iron Enzyme HppE with 2-Hydroxy-3-methylenecyclopropyl Radical Clock Substrates

[Image: see text] (S)-2-Hydroxypropylphosphonic acid [(S)-HPP] epoxidase (HppE) is a mononuclear iron enzyme that catalyzes the last step in the biosynthesis of the antibiotic fosfomycin. HppE also processes the (R)-enantiomer of HPP but converts it to 2-oxo-propylphosphonic acid. In this study, all...

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Bibliographische Detailangaben
Hauptverfasser: Huang, Hui, Chang, Wei-Chen, Lin, Geng-Min, Romo, Anthony, Pai, Pei-Jing, Russell, William K., Russell, David H., Liu, Hung-Wen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004275/
https://ncbi.nlm.nih.gov/pubmed/24512048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4100035
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