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An Unprecedented Nucleic Acid Capture Mechanism for Excision of DNA Damage
DNA glycosylases that remove alkylated and deaminated purine nucleobases are essential DNA repair enzymes that protect the genome, and at the same time confound cancer alkylation therapy, by excising cytotoxic N3-methyladenine bases formed by DNA targeting anticancer compounds. The basis for glycosy...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160814/ https://ncbi.nlm.nih.gov/pubmed/20927102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09428 |
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