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A New Protein Architecture for Processing Alkylation Damaged DNA: The Crystal Structure of DNA Glycosylase AlkD

DNA glycosylases safeguard the genome by locating and excising chemically modified bases from DNA. AlkD is a recently discovered bacterial DNA glycosylase that removes positively charged methylpurines from DNA, and was predicted to adopt a protein fold distinct from other DNA repair proteins. The cr...

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Autori principali: Rubinson, Emily H., Metz, Audrey H., O'Quin, Jami, Eichman, Brandt F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763988/
https://ncbi.nlm.nih.gov/pubmed/18585735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.078
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