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The substrate binding interface of alkylpurine DNA glycosylase AlkD

Tandem helical repeats have emerged as an important DNA binding architecture. DNA glycosylase AlkD, which excises N3- and N7-alkylated nucleobases, uses repeating helical motifs to bind duplex DNA and to selectively pause at non-Watson-Crick base pairs. Remodeling of the DNA backbone promotes nucleo...

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Detalhes bibliográficos
Main Authors: Mullins, Elwood A., Rubinson, Emily H., Eichman, Brandt F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039204/
https://ncbi.nlm.nih.gov/pubmed/24286669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.10.009
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