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Depurination of N7-methylguanine by DNA glycosylase AlkD is dependent on the DNA backbone
DNA glycosylase AlkD excises N7-methylguanine (7mG) by a unique but unknown mechanism, in which the damaged nucleotide is positioned away from the protein and the phosphate backbone distorted. Here, we show by methylphosphonate substitution that a phosphate proximal to the lesion has a significant e...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3852881/ https://ncbi.nlm.nih.gov/pubmed/24090276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401195r |
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