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Probing the Active Site Steric Flexibility of HIV-1 Reverse Transcriptase: Different Constraints for DNA- versus RNA-Templated Synthesis()
The steric flexibility or rigidity of polymerase active sites may play an important role in their fidelity of nucleic acid synthesis. In this regard, reverse transcriptases offer an unusual opportunity to compare two enzymatic activities that proceed in the same active site. For HIV-1 reverse transc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160155/ https://ncbi.nlm.nih.gov/pubmed/18366188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi702427y |
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